	   SnapGene      ôGACGGATCGGGAGATCTCCCGATCCCCTATGGTGCACTCTCAGTACAATCTGCTCTGATGCCGCATAGTTAAGCCAGTATCTGCTCCCTGCTTGTGTGTTGGAGGTCGCTGAGTAGTGCGCGAGCAAAATTTAAGCTACAACAAGGCAAGGCTTGACCGACAATTGCATGAAGAATCTGCTTAGGGTTAGGCGTTTTGCGCTGCTTCGCGATGTACGGGCCAGATATACGCGTTGACATTGATTATTGACTAGTTATTAATAGTAATCAATTACGGGGTCATTAGTTCATAGCCCATATATGGAGTTCCGCGTTACATAACTTACGGTAAATGGCCCGCCTGGCTGACCGCCCAACGACCCCCGCCCATTGACGTCAATAATGACGTATGTTCCCATAGTAACGCCAATAGGGACTTTCCATTGACGTCAATGGGTGGAGTATTTACGGTAAACTGCCCACTTGGCAGTACATCAAGTGTATCATATGCCAAGTACGCCCCCTATTGACGTCAATGACGGTAAATGGCCCGCCTGGCATTATGCCCAGTACATGACCTTATGGGACTTTCCTACTTGGCAGTACATCTACGTATTAGTCATCGCTATTACCATGGTGATGCGGTTTTGGCAGTACATCAATGGGCGTGGATAGCGGTTTGACTCACGGGGATTTCCAAGTCTCCACCCCATTGACGTCAATGGGAGTTTGTTTTGGCACCAAAATCAACGGGACTTTCCAAAATGTCGTAACAACTCCGCCCCATTGACGCAAATGGGCGGTAGGCGTGTACGGTGGGAGGTCTATATAAGCAGAGCTCTCTGGCTAACTAGAGAACCCACTGCTTACTGGCTTATCGAAATTAATACGACTCACTATAGGGAGACCCAAGCTGGCTAGCGTTTAAACTTAAGCTTGGTACCGAGCTCGGATCCgccaccatggaaggaggcggcggccgcgatgagccttcagcctgccgggcaggggacgtgaacatggatgaccctaagaaggaagacattcttcttttggccgatgaaaaatttgacttcgatctttcattgtcttcttcgagtgcaaatgaagatgatgaagtcttcttcggaccctttggacataaagaaagatgtattgctgccagcttggaattaaataatccggttcccgaacagcctccgttgcccacatctgagagtccctttgcctggagccctctggccggggagaagttcgtggaggtgtacaaagaagctcacttactggctttacacattgagagcagcagccggaaccaggcagcccaagctgccaagcctgaagaccctcggagccagggcgtggaaagattcatacaggagtcaaaattaaaaataaacctctttgagaaagaaaaggaaatgaagaaaagccccacgtctcttaaaagggagacatactacctgtcagacagccccttgctggggccccctgtgggtgagcctcggctcttggcctcctccccggccctgcccagctctggtgcccaggcccgcctcacccgggcgccggggcctccgcactctgctcatgctttgcccagggaatcatgcactgctcatgctgcaagtcaggcagcgactcagaggaagcccgggaccaaattgctgctgcctcgagcggcctctgttagaggaagaagcatccctggggctgcggagaagcccaagaaagagattccagctagtccttccaggacaaaaatcccagctgagaaggaatcccaccgggatgttctccctgacaaacctgccccgggtgctgtcaatgtgccggccgccggaagccacttgggccagggcaagcgggcgatccctgttccaaacaagttggggctgaagaagaccctgttaaaagcacccggctctaccagcaatctcgcaaggaagtcctcctcggggcctgtttggagcggggcatccagtgcgtgcacatccccagcagtgggcaaagctaaatcaagtgaatttgcaagtattcctgcaaatagctcccggcctctgtcaaacatcagcaagtcaggcagaatgggacccgccatgctgcggccagctctgcctgcaggccctgtgggggcatcctcctggcaggccaagcgggtcgatgtttctgagctggcagcggagcagctcacggcacccccctcagcatcccccacccaaccccagactccggaaggtggcggccagtggctgaactccagttgcgcttggtcagaatcttctcaattgaataagactagaagtatcagacggcgagattcctgtctaaattccaagacaaaggttatgcctactcctacaaatcaatttaaaattcctaagttttctattggtgactccccggacagctcaacaccaaagctttcgcgggcacagcggccgcagtcgtgcacgtcagttggcagggtcactgtccacagcaccccggttagacgctcatctgggccagcaccacaaagcctgctgagcgcatggcgtgtgtcagccttgcccacacccgccagccggcgctgctctggccttccaccgatgacccccaaaacgatgcccagggccgtgggctctcccctgtgtgtgccagctcggagacgttcctctgagccccgcaagaactctgcaatgagaactgaaccaacaagggagagcaacagaaagacagattccaggctggtggatgtgtcccctgacaggggttctcctccttcccgtgtgcctcaggcacttaacttttctccagaggaaagcgattctactttctccaaaagtactgccacagaagtagctcgggaggaagccaagccgggtggagatgcagcccctagtgaggctcttcttgtagatatcaaactggaaccactcgcggtcactccagatgctgcaagccagcccctcattgaccttcctctcatcgacttctgcgataccccagaagcacacgtggctgtaggatctgaaagcaggcctctgatcgacctcatgacaaacactccagacatgaataaaaatgtggccaaaccttcaccggtggtgggacagctcatagacctgagctcccctctgatccagctgagccctgaggctgacaaggagaacgtggattccccactcctcaagttcCTCGAGGACTACAAAGACCATGACGGTGATTATAAAGATCATGACATCGACTACAAGGATGACGATGACAAGTAGTGAGGGCCCGTTTAAACCCGCTGATCAGCCTCGACTGTGCCTTCTAGTTGCCAGCCATCTGTTGTTTGCCCCTCCCCCGTGCCTTCCTTGACCCTGGAAGGTGCCACTCCCACTGTCCTTTCCTAATAAAATGAGGAAATTGCATCGCATTGTCTGAGTAGGTGTCATTCTATTCTGGGGGGTGGGGTGGGGCAGGACAGCAAGGGGGAGGATTGGGAAGACAATAGCAGGCATGCTGGGGATGCGGTGGGCTCTATGGCTTCTGAGGCGGAAAGAACCAGCTGGGGCTCTAGGGGGTATCCCCACGCGCCCTGTAGCGGCGCATTAAGCGCGGCGGGTGTGGTGGTTACGCGCAGCGTGACCGCTACACTTGCCAGCGCCCTAGCGCCCGCTCCTTTCGCTTTCTTCCCTTCCTTTCTCGCCACGTTCGCCGGCTTTCCCCGTCAAGCTCTAAATCGGGGGCTCCCTTTAGGGTTCCGATTTAGTGCTTTACGGCACCTCGACCCCAAAAAACTTGATTAGGGTGATGGTTCACGTAGTGGGCCATCGCCCTGATAGACGGTTTTTCGCCCTTTGACGTTGGAGTCCACGTTCTTTAATAGTGGACTCTTGTTCCAAACTGGAACAACACTCAACCCTATCTCGGTCTATTCTTTTGATTTATAAGGGATTTTGCCGATTTCGGCCTATTGGTTAAAAAATGAGCTGATTTAACAAAAATTTAACGCGAATTAATTCTGTGGAATGTGTGTCAGTTAGGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCAGGTGTGGAAAGTCCCCAGGCTCCCCAGCAGGCAGAAGTATGCAAAGCATGCATCTCAATTAGTCAGCAACCATAGTCCCGCCCCTAACTCCGCCCATCCCGCCCCTAACTCCGCCCAGTTCCGCCCATTCTCCGCCCCATGGCTGACTAATTTTTTTTATTTATGCAGAGGCCGAGGCCGCCTCTGCCTCTGAGCTATTCCAGAAGTAGTGAGGAGGCTTTTTTGGAGGCCTAGGCTTTTGCAAAAAGCTCCCGGGAGCTTGTATATCCATTTTCGGATCTGATCAAGAGACAGGATGAGGATCGTTTCGCATGATTGAACAAGATGGATTGCACGCAGGTTCTCCGGCCGCTTGGGTGGAGAGGCTATTCGGCTATGACTGGGCACAACAGACAATCGGCTGCTCTGATGCCGCCGTGTTCCGGCTGTCAGCGCAGGGGCGCCCGGTTCTTTTTGTCAAGACCGACCTGTCCGGTGCCCTGAATGAACTGCAGGACGAGGCAGCGCGGCTATCGTGGCTGGCCACGACGGGCGTTCCTTGCGCAGCTGTGCTCGACGTTGTCACTGAAGCGGGAAGGGACTGGCTGCTATTGGGCGAAGTGCCGGGGCAGGATCTCCTGTCATCTCACCTTGCTCCTGCCGAGAAAGTATCCATCATGGCTGATGCAATGCGGCGGCTGCATACGCTTGATCCGGCTACCTGCCCATTCGACCACCAAGCGAAACATCGCATCGAGCGAGCACGTACTCGGATGGAAGCCGGTCTTGTCGATCAGGATGATCTGGACGAAGAGCATCAGGGGCTCGCGCCAGCCGAACTGTTCGCCAGGCTCAAGGCGCGCATGCCCGACGGCGAGGATCTCGTCGTGACCCATGGCGATGCCTGCTTGCCGAATATCATGGTGGAAAATGGCCGCTTTTCTGGATTCATCGACTGTGGCCGGCTGGGTGTGGCGGACCGCTATCAGGACATAGCGTTGGCTACCCGTGATATTGCTGAAGAGCTTGGCGGCGAATGGGCTGACCGCTTCCTCGTGCTTTACGGTATCGCCGCTCCCGATTCGCAGCGCATCGCCTTCTATCGCCTTCTTGACGAGTTCTTCTGAGCGGGACTCTGGGGTTCGAAATGACCGACCAAGCGACGCCCAACCTGCCATCACGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGGTTGGGCTTCGGAATCGTTTTCCGGGACGCCGGCTGGATGATCCTCCAGCGCGGGGATCTCATGCTGGAGTTCTTCGCCCACCCCAACTTGTTTATTGCAGCTTATAATGGTTACAAATAAAGCAATAGCATCACAAATTTCACAAATAAAGCATTTTTTTCACTGCATTCTAGTTGTGGTTTGTCCAAACTCATCAATGTATCTTATCATGTCTGTATACCGTCGACCTCTAGCTAGAGCTTGGCGTAATCATGGTCATAGCTGTTTCCTGTGTGAAATTGTTATCCGCTCACAATTCCACACAACATACGAGCCGGAAGCATAAAGTGTAAAGCCTGGGGTGCCTAATGAGTGAGCTAACTCACATTAATTGCGTTGCGCTCACTGCCCGCTTTCCAGTCGGGAAACCTGTCGTGCCAGCTGCATTAATGAATCGGCCAACGCGCGGGGAGAGGCGGTTTGCGTATTGGGCGCTCTTCCGCTTCCTCGCTCACTGACTCGCTGCGCTCGGTCGTTCGGCTGCGGCGAGCGGTATCAGCTCACTCAAAGGCGGTAATACGGTTATCCACAGAATCAGGGGATAACGCAGGAAAGAACATGTGAGCAAAAGGCCAGCAAAAGGCCAGGAACCGTAAAAAGGCCGCGTTGCTGGCGTTTTTCCATAGGCTCCGCCCCCCTGACGAGCATCACAAAAATCGACGCTCAAGTCAGAGGTGGCGAAACCCGACAGGACTATAAAGATACCAGGCGTTTCCCCCTGGAAGCTCCCTCGTGCGCTCTCCTGTTCCGACCCTGCCGCTTACCGGATACCTGTCCGCCTTTCTCCCTTCGGGAAGCGTGGCGCTTTCTCATAGCTCACGCTGTAGGTATCTCAGTTCGGTGTAGGTCGTTCGCTCCAAGCTGGGCTGTGTGCACGAACCCCCCGTTCAGCCCGACCGCTGCGCCTTATCCGGTAACTATCGTCTTGAGTCCAACCCGGTAAGACACGACTTATCGCCACTGGCAGCAGCCACTGGTAACAGGATTAGCAGAGCGAGGTATGTAGGCGGTGCTACAGAGTTCTTGAAGTGGTGGCCTAACTACGGCTACACTAGAAGAACAGTATTTGGTATCTGCGCTCTGCTGAAGCCAGTTACCTTCGGAAAAAGAGTTGGTAGCTCTTGATCCGGCAAACAAACCACCGCTGGTAGCGGTTTTTTTGTTTGCAAGCAGCAGATTACGCGCAGAAAAAAAGGATCTCAAGAAGATCCTTTGATCTTTTCTACGGGGTCTGACGCTCAGTGGAACGAAAACTCACGTTAAGGGATTTTGGTCATGAGATTATCAAAAAGGATCTTCACCTAGATCCTTTTAAATTAAAAATGAAGTTTTAAATCAATCTAAAGTATATATGAGTAAACTTGGTCTGACAGTTACCAATGCTTAATCAGTGAGGCACCTATCTCAGCGATCTGTCTATTTCGTTCATCCATAGTTGCCTGACTCCCCGTCGTGTAGATAACTACGATACGGGAGGGCTTACCATCTGGCCCCAGTGCTGCAATGATACCGCGAGACCCACGCTCACCGGCTCCAGATTTATCAGCAATAAACCAGCCAGCCGGAAGGGCCGAGCGCAGAAGTGGTCCTGCAACTTTATCCGCCTCCATCCAGTCTATTAATTGTTGCCGGGAAGCTAGAGTAAGTAGTTCGCCAGTTAATAGTTTGCGCAACGTTGTTGCCATTGCTACAGGCATCGTGGTGTCACGCTCGTCGTTTGGTATGGCTTCATTCAGCTCCGGTTCCCAACGATCAAGGCGAGTTACATGATCCCCCATGTTGTGCAAAAAAGCGGTTAGCTCCTTCGGTCCTCCGATCGTTGTCAGAAGTAAGTTGGCCGCAGTGTTATCACTCATGGTTATGGCAGCACTGCATAATTCTCTTACTGTCATGCCATCCGTAAGATGCTTTTCTGTGACTGGTGAGTACTCAACCAAGTCATTCTGAGAATAGTGTATGCGGCGACCGAGTTGCTCTTGCCCGGCGTCAATACGGGATAATACCGCGCCACATAGCAGAACTTTAAAAGTGCTCATCATTGGAAAACGTTCTTCGGGGCGAAAACTCTCAAGGATCTTACCGCTGTTGAGATCCAGTTCGATGTAACCCACTCGTGCACCCAACTGATCTTCAGCATCTTTTACTTTCACCAGCGTTTCTGGGTGAGCAAAAACAGGAAGGCAAAATGCCGCAAAAAAGGGAATAAGGGCGACACGGAAATGTTGAATACTCATACTCTTCCTTTTTCAATATTATTGAAGCATTTATCAGGGTTATTGTCTCATGAGCGGATACATATTTGAATGTATTTAGAAAAATAAACAAATAGGGGTTCCGCGCACATTTCCCCGAAAAGTGCCACCTGACGTC  Aé   %   %      )      *   !      %            )   "   2   ,            #   1   !                  "                )                                 $      "         '         "   .   $          6      %   :   '   ,   (   6      "      +      '                     #   +   -   %       %   $   .   .   ?   (      !                           %                                     #   "                                        "                $   #      .   $         *                  "   &   2                  !                                 "         #                     *   %         +   /               "   #   $      ,      $          %   $   *   $          '                  	               %   .   +         =   )   .         !         &               )   -   $   1                      (   &      /   '   3   *         2   :   #      "   .      !   &   &   2   (   ;        % šÙÆµ—M�Ÿ=>©
PQRW\kl�»ÄÅij“;þ;½ÛHÊ{·É%  š1›½ÙoÚÇ“,aæv
	ýmvŽ:Ü3 ¾IËÈ pzG · °ÁWŒ	ª
SXÆïw©–A‘<Ü|!�Ê) Ø �Ô7¶˜&,4N� ¿?h	²	
&
£]˜¼k¼\”ð/<ÿØŒ^tÐ¸O 	 d -´¾p²¸ÈÔ0L”Ÿšp@
w

6nå³¿ÝEËJq* ®öz	=s-YˆÛ‚£Ú
Iÿ&w­…œäÑg“ÅÖû�ÉþŒÌ©0HX!  ‡œ çç˜
ª?�q�;ò
%AÍæ7z¬¿Ì®‡[¡¼{È¢ ›2ÚÛQZbÅN	þZbûÌ ïš¦4¡c%  ±e×Âï§C	•
÷úm@TY•ðõª—ßB¸d’ÝRø¡·U1" E¿”Çòœ±ëA[€–Ý
+h ¸ mŽ‰	¢	«
øx°ÐS1œ=ˆö;R¹1}²ñ�Ë g XÉ�	U$Ø‡‡þ}¨á¿) ½ ‚µ¸85ªóÑ	ò	ªÞì•ñ0"2J—ÎÑ|O_•®UtÑž�Yo¹P" � Ï@sÊÕK-¡À@Kj|i	ˆ	Å
^…�´ü]Ò=s#M÷42 • U6Q}ïÌ™Ol´'
‘
1£-™¡½Pl¨ðk¶ÈJRm†Úã%q‚• �²Ù�¨�"Åuªm, Ù L»Â·Óß÷{'‘ñ$5O­q	³	ý	 
·è¤½KˆŽÂ9çn‰=ëöº�ÑÜ e ³ÕW†Ø
/+X¡$o¨†Œ±´ÀHÐ5MP”!r 
 ?q¨Éüh• ¯ÖöA
e
x
7þF`gK®šJØ n .µ¿2ªM;æ%ÌçPªú�4`# y -šÄ¹þ1Åw›eqÉ	N
z
$^žÞ½ÁöÈ/vÀë˜ã3�Õ%ž1 © ¯ó÷<EËá&yZ‰Œ¢ØSVƒ¤çÿ
˜ x¸ ©3ÒóÅÆ‚Ê²ÏîdÝÍÜÒ1‚! Yc>jnt|«‚
Û
°'®�åb°hB„œ×XÿS‘ª¼Y¹ß ¬ {.ÜÒÎÜÜx†À[Ô”8ÄLIa® Aá�
¸Y
g
l
J9²ÄÛüÒ�’ 8 Ñ hÁè?Bgè\

™
 _Ž”�­"vuÎçM­ ä Þ ˆ>�É¼Ím¯bk’|£ ð �B±øŠ
á
@pr~¤1<Ec&{ioˆH¢°±"    ¡8«¾y¶óøB�áê8°À\go½É2‡™ÇÉÚþ   r~§ú´þÜð§	C
j‘ÍßÍí	ð/"S¢0C‚í ž ê ú[—§Æô	O	†
¥
Ê×ÿ1—c{ f§_`	S ÷ œ3“ÛdQ�âF	†[…ÀüoX!ƒ5ydeR-  š Yd)sëR)cY
wÂ
dù•«¯¥C›ÝGKjž/œ\) ²…Ò;¿½;¨²$
–
¡æøû=UZ–óöºùƒšâCáe‡•9SÏµ¸ŠßS fßÃÐD	-nŸ«¯Aºšéá+2# ] _ ÜØÔ	Ö	2
4
œ
»
AñŠŒ˜à“˜Ðù]VãQ  s 4ð©­{	6
½
Äî„¹6éÞ'�¢ˆ¦�òä p ;§œ=Ù·¬èû›,_ FŽÀëÒ²B\�üÕç L �·ÞNjÜêÈ»äfóP`Y�ì—×ÞòiS² * Ô Óì#Dw•Úô
Ç6 a ç ›JÀ…	ÎÜâ¯‰6 K	;>£ËÙbÕ^ C ¹ ü 7‚_	£	ùT’÷¢ºõ›)’³åò‘ À n�ÁÅ„–_9	©ßÑ™ã<‘Sw2:à0d$ 0…ŠÎë?F
¬
QIy±îT2��ô'>Î‹™ô&¬@!~°àÌ h èYx	Þ>g$ˆÿZa" uªýT·O£G	øÊ�	Ž	Ø	VCZŽÔŠ¦JˆL©XÎBr ¦ )Hˆÿ7%Ù\K~7þ— ¬¼†”	ž
è¡é)´@¶RâÀ' kŒ	¶¹y�2�"Un«f	o	S“«ÜêíØ}€˜Ï1»FP“š¯Ÿ/°W  w Ï ¿O6ôß
�v1®¿3KÒQ–V’0˜ŽZºQ ¾ å 5ƒ‚9«Ò	ò­}þWuÍp" u Å ÃË	ó	Òßèþ Ž–Öû#%	¹D`��Ò6äN×4…Ñ. ÐAt*Ö Lº2Lksu	‰	#´_‚ ±µùýƒ.�ÉÓý>êÓtw�BEPÙàø�$ { ‘ 6C.v~ÁØäU
`
|
eg¿Ø Ïxåð>�ºç6¨'5?  > ¥ �¢A‰Í	-2†áÄÈ†¸ø'	 .É05N … ! Ë5f¯}j	}	›	¸	Æ
›Ž*^Ã$ûôÓ6 k Ç Vzo²@lošÓPgµÆ	õ	’
b¤!.³Š¸`ln‡ä &rƒŽÂÚ©ÈŽ-~�å3ë(ŠÒ † Z7~¸Æ KSÛ)–Ÿ³rí¤ÆG% Y – ² Ê JR�vð"Å`	¢/Q†·Éà=ŒTrÊáëŽíxj§Ôvn#: 3 R /œäÍê:më)vS	ª	ø	(
<
2š¾&_m©ñÖqWû©brƒ£#F…‘ßæ…£«]x·eŸ' ; ¼Ñ	Ã	r	ï	!
MB‰�:y|8]ÕXoŠøx¥Â	¤ÉÒÝ<, H Ú “ç¦r3(%P®´	ë	8
ù
iéÑÕD¾è_)>ì÷mzñÅ%A‡æ( QÆÍ•´"ÇÔür|’ò.	Â	Ü	þ	¿
¸»ÆðL’˜ÃP{×àº8»Nó6 #M]kÇðöž»�«¸àåòø']¥ý6á	
P
&m&¥ãÔ"ÄØ.:COYd˜»�+VÕ(+‚k ¶ ™nØ6’++‹	
u
¨
¢jÃv¨9•’ýÉŸsÏFNŽÈ" ±õKrX‡ÄÚ�Ù
©5YŒ%ap²	Ë@å6¥Õúb†Z»Ç/ f Ö¦	?Þ0‡Qêý•+ � ” ¼ ´öJ
4N�
Ä
0¶,„©§³ïû‡�µÁÇIÑ!N­êõ!s�"LŒ3 ,>©ýV…®y
×
…ýGõÇuLO�©' « @òbÊàim{‹¡ª×UÍæX
f
�
þ
—8±·ÿ¨aÃÚÎÑRcÛÑK‘¸  Ý >fA°÷‰
=^x!hlGf¯Èa°Ù rù(–¦Xœáï	¦	B
…
Ö	czÌÿeª_› r Û3¨¼Ï±,žƒ¹ø®5Ïè´‰‡ÞâPœã ) K o �¶Òë"CvÛéó
›<º«eÖñûÔ5 B û /ÀÍI¿8	„	PÍ‘S&Í5ó«ôßJ (/‘Øaß S¥G«NF»…w	ç Óè(KQýA# ‹�Nx1œTmn	Ê	Þ
Ûç�Õ­¾¬0P¸™Ì‘./Ö¯Ÿ+ z )ÿŽeu¹rˆš	·	{
š³f�°Ã×øÂ÷Èäï4vŒAD¹úŽ&„- … .y�›uãé·ÒÅê(fuR	_	;
 ·^_ŸÕßÿÉìqw�ì,¢„Þw¶% G "ÅÌ”º!2€ªÆ\¤Á	Û	î	O
%hl%ºÔÔ
ÁÖ*yðÄÈ  Ž “ °ôq‘Ù€¥	t
4‹i8 †¬éôYžºÎ‹Æ2EM% ª ñø=aeß'@lzŠ©­TWà
	W
„
bwy°ü ©ôÆÙk^Ðbe$ Úê¤FÌEH„ÎÚè7	ò
 OšŸ¹çª4dÎJ³ÞðÝÓ×@›â. F „ (xŽâ [�£0dÄS^	À	Ý
g™²æ]Â
Ô¬ÓOÇÕƒËï@®ƒ. `dÞ?kp~�¬cÃ	]	¿	ƒ
Ü
ñ
±av¯žÁæ	Óc… ÍÔ«ØèójX¹ï­šDá? } ÐãRXYo}�ÉÊb.	
ð
àá›œ�WXYklÑÒiçò<= TUVW’·¸×Øª«¬™«½)*7ABCº»à( ~ H	ÑäZ8€SZugËÉæ	$	/	â (dZmjCü�>ÒÙå8Z¼Ä Âˆ^÷Dû
DÍì­ž±DY “þ¿¬¾+À! I{­ 
~ºå9vb
ã![‡ÁzkÕDóMä5Ú�9[¯ x–_�[çÝÝ~õ\ý´¼,MuJby½Å  ¡ [|ThÓØ	)	0	)ny}Ïsž¯úÓ . ­ Ò„/ÌÝxÊÏ%	ei•�9Å?æê a�Ö
:sAÐŽ8„­ ‹ íâ‘EüW	q
~
Îhb²¹ÜƒÓ,Á >Ãð:‰¹Z
h
Ì
EŸ	4IÅÞEðD¿”ÿeé“¿ú B_ø–m
Kí®³Ú"ZýZV!À<é  +J®/c»¬åÏ	Ÿ®i#oÏHblÖô…kïõ% § |'Âé:@Cw	
c
ÈÚh}�•"\VÂèE‚®å6¬Ûø�—œ Ò ƒæhé]š
äˆNZß™¡å\° 9 åi 3>	
!`ˆ‘½Æ�wv{)NÆ!U: @  ‹—‰lèÊö&ª‹ÜH-NŒÆ <y&^‚\ÞÞt6ñþËÎhc½}K¾ ß ')ã$?æ]½ôöz¨ á `Gš�ˆb¼µn°l“v€ci¤  ¢ í ô o¤÷±û&lùiÙ@	t*4sP',¿çŸû[D¦” ñ ÿ P]\}Uqã¥zÐ÷2‰I±Ô| € ¹žÔ*	2=Fdot}ìj"Ù£;²‡ª´× ýC²Þù	1	‹
â
AFK)~]£N¡|p0°sE  WVƒ¿‚/fÁjÞµº€õ–:@HjPÈ# 	×à{Ó0Ëÿì&	Az·ùlâú_¢bJW‚ŸÆ7´ç¶ˆè£‹"  / N ® H¤yÐ®	¬ØÊôCMë9ÁRîà]p¾ë*3}Êÿ  ¢…‘ÍÞ9¤³C‹Ê>èh‘±¥½=hÊDïùšÛ  Ö C½˜×zñk‹Îî0ð·ÃynxV bb
’Îëñ#e¾1c�i… s¨ûLµÝ†	D
Ÿ;Gµàì
Å™9®î ã ‘îÿ¨	Ðüt,ŠT£BÑDãLƒ¡[ ’I¨P	l	˜	
‡
¦
ü
 dcÁ`„§Ô
J-  , ‰ Œ Ÿ îÜÇõF	"	½	r
Ë2_‰˜|i`gú­·:Â ë :Õ%Fyãû\¢÷˜±ýØ€³¨ºõÝ•Š¦Õ õX	å	�ÏµaÉT ÄGNì7‘	i
ö
FÁ
YÆ"„+	vp}ý.û ø ;iœã\†peEÀËf ?�Ë4<ÜŠè"È
Í
ç
‡ ßf ê”" # ”ñeRžº	G	[
OYÑH	ý5JÉ6Fñz§•Së8Àîek › Z—ã
ô¬œÞHudþ«0%•§]‚Ï `Í©drZ	º	n
Le´Û#¦©Lp"zÁ= *`ŸùxÃî�°R™[k ²øÄ&é  e¬CtìS*Zh’—�	ç	
’¯ú–D¶Ù[ŸW�êö$ ¯0€¼´À–%L¾<±	%
üOV[uŒ—º»@[.�×:‹Ú] # c ,³†­æYy·Ó<™—
H>þäú„›ã¾$DÐîfy«Ê€‹¨  d“îÈB	”
ùô÷¯Rcõ:†¶Ü	*§àTgð0. KTÎ?rÉ5P|ÁîÒJi©³‡	Ð	ü	¢ç jâæ$pImˆ–±Í{TÐr¹€lÛö$ m Ã§ûgÄÕdÈ	M
d
.#* #:§]�°.æêâO­ù 3I×$� ¨ à;D%xRÑ·Ûk
¯Û¿ÃÄƒ›7±íÜ`�­ 7 ï gA½oµ£¬È0b÷ut�é»¯n‘˜ý* ™ é ö Xq}¦ù(’³ýêóE	

¤
vÉ0i~�–øÞnWBÜ!Fx/�Q,ì \ ^ ¾:Õ	1
3
5
›
¼
åÃò‚‰‹™á†”8—™à¥* Ó ÝiÙ:¦ØãO_Ñçúš^Ræ± ` „Ä�ê>^•^ÛÞ€â�¡˜9=¢äÔ] ç(¢÷þ“	×	�
6B�‰¥³IÝ?[#µ6WÍ– t Ä jœª!ÂŒ’ú|ýV€’Ž5ã3V"   ¤ 54B®×ã1|	_
"d,¾Ç‚Î)Èw…é-/=Œæ§ÿó& 2 Q X ± É In±!9?knÅ	÷	a‰…p(VSÁêÇ£ê‰F"dž2 : ÆæÐq�³äñ&qü-	à	
7
¾
ø
ÅÐâïA—xº7\œ*OW^ß(£M@j;å µ » ˜m¨>Âu§”Æ éüœÇ =„å¥	<ËtÍÇ`· A q ú ŒRº+�Ì‚¸÷Ò'­4I.O !Š€é€Ú«pŒÝ‹-µ� E ƒ '�ðß6	å7]�ÖL! GÁ‡_W]ŽaÈ	-	ßu¬cVÿÌÓiÑÖäîý¾˜¿ z^ƒô|rò€ãù4³+~ =�ì9Ë
gr3HïÏC‚¾dè  *‚ä.	ž¼€U�˜÷jôT à (#%ks5åðagóõ ó þ ¸öO\kÝ?	J(O|¢M+¾æZØ:{~“©³ M ßUë@ÉçÝg^¡ôQV¤ž¼í<Giß³)µîçŠ Õ â B¼íKaûŠ‰ï½¶ÂKxhmw + ˆ 9Ô$ExÛôH!	^ˆù¦ÈI”¥ ;Më›	æ
õ
È7dj _–žq‘˜µcoª±÷y”�Î" b Í>qÈ’XxÑ$K˜ÇA	†	tãQ½?-°ÌŠz\Û¦fÚ§ ˜ è î õ p¥ø‘²üúfÚu÷¢Ý/Ž N°mÖ_€¬ [ Ã'9Ý5â¤Üá7> 8<¤Ì•# £ Ã mœ²°%jÖÁß	Ïá+@Í(ùUVÀèüU<L
2?Eci ´ º Qƒ¤	t�¦“ÑŠ´¶ D ‚  ]†Œ~V�`,	Ê
«äóUfq{ø3œÐÕã*— ò ý -T	r4{åïU£»;h²´íæó}‰’ 8A»^Lêóú‰îø©öJx“Í Â p�ÂÇW±e$—ÕàÜ.?¼Ì£=TÚ7;l¥1e« � º…ò+	ªs€ˆò3epz~íäÏâ³ì–ˆµ* Á oÆ:	Ï
ÒÓ->uvwxy¹º»Ëí¡¢tš#$%&3456s¤Îá%st% Ÿ6ŸÞ"`;	b	Ð
é
+1>SÔGîuk›'’x½Öt<&uØ Ì /NÏc	,JÕHïO¢?l�ÒŒÅõû="¼´á É#Dñ²}('ÁAptv+ þ,KìaÓ<	­
Ñ
ã
ê
6‰ÉGL¤2?ï*^3žv(+~Ï1¾×­u'F±/ 1† 7 ß‹³À@ßú	2	
G
Œ
¶
{BRó5:TzU¤‚õãqœ“±flyšoÍÙ  žO.Ê�>
g"IðPkË‘;…�Æöü½µ W0uZ„ÀVƒ¾“£»ß�@mhAâ éÐy	ß<?ç—%‰‹ I>[Q_bÉð i Í X|d	Q0-BKÂÖ¶öÓp|k#" ' Ê¤HT †Ëí‚	Ù	Â
¸�Õ‹ãû£ ÇMñ(‡-·uÏŒ# 
v«Øþ|¸ÔP
ÌùÖ'	U	BM[Íú§K©H`µè‰:sÄw$ áU$E1<¬	r�Æ{DKm`~ÄHXƒ‰ÚªBqíC¡¤gš –gæÿx�	Wò³Pc)«ót¥8á—Â¥Yé, 0 5 O ¯ 3¥¿ìõ+b¯	ú	K
]
Š­»Ù8M¥€•›õsìw,8]áè4~(G I!o 	=	ä
ÊHœÀa&2nvì8ÿ$ ÿ *-ILc‹ÏÑ473ðÿ+ŸÚ)ÐSdL®q¿	g²Ë 	m   % §1‰ízÔ*
®
Ò
ë
@ Ë_4DN:Â“¿Øï^+Â˜ 2ó£†˜ {7LVa6ƒµ’�¦g%›·>ðzÄÎ% ¡¡©à´ÁA¥¼	•	
�
Ô
í
[Óé¥éirµA²¾SE­öúÜ$ 8×½‡ŠàDGû	3	H
°
³
|JSô(;öFYä²”m•iËã¹Áp*   T ‡Œ­Ú’Îßï:´íŒI	,
Ÿ
·
CèË6Uo¢«êó*?Øýz‡ÁU€›Ú$  × ™ØÓÅ`å3ŽžVg	îhÛï:2Ÿ¼GÇzoy¶  ŸP/žo¢M	?
¬ñÌ™’Ä­ýËW¡  D¾l�
ˆ¡	Töl”Ï#›·×ñQ†›°¸÷@Z 0|±¾' ·ºËÞzkð#{¬òp	ñ	ÝëOŒJ8Ql…Ù~�”1ŒÐ§<Ž”Ä©Xn x ™1võW‹Ï_¼À4$f¿—2“™Ô�_ X�w2¯òZÓAW�»Þ  Ð À7[

à
Ž“}DàL n1j†Æã � ccP…Á„¿”®ì¤.‚JRiB^�.d[R „ÞÑ:¬z	Ó	#
º
 <í~à@¹è&ŒÎ\Rñ	 €Mê¶Æ~X  ¿ æ 6ƒšE
¨Háíó®˜ÿŠv%š?:cÊ¯ t©ü¶‡€	Y=fJY`qï v Î ä 4¾e	RÑéýu×$ºCEM—„Ð =  }t	Ì	T
1àÿ-�ü·&
ÒOØ5ß>Ò% j Æ YÄ©	ô	²
%.<‹qžàú¨aiq}‚E�¦Óä2å'„¢\Ñ. P\j’ïõ¥ûê	Ó!CLÃ×-9BNXc‘{—÷Uwz¤Ô'¹7lò$†+ ×5Jõ*IÃ*	3MŠ	
�
§
Ã
µ`ƒ¦²Ýîú/‘Ê?äü¤ÈÔùar…K.� Ü +¥U›Ìî€
ˆ
Ö
ý
]–Õ¶þ„§dÂNŽ¨FQ¯ÚÐ� ( J Ñ!Bu§»°¾v	ƒ	�RòÕóˆ†ü'áÞ= Ët“©èM¶Ñt¸'lt‡Q	m	™	¶	Ú	í	:
$k¹Óe¶¯Ö÷ŒÔþ	·ë+¡î)uxC.¸ÃÇvù) � ’ Ùé£wD¨/GÍÙR		V
s
f3NŠ™h\û¨«NI
?aŠ?Å. | Ïâ7ÝQfÈöCÂåú	#	\	¾	
ï
CÌë`šjÀÐûCªæñ;¶©(6@Ã -   w•¬ÿ}¹w×(	a
}ÎhyL®éŽ»tx Š `Õï•V	p
}
Ù!aYÝ¸@Uè7ƒ;ù! ¦ &b«ä2=Î	ÇÙg|‡Åhn(GaÅY„Þ«– î› ? &;Šâ]F™%‡©Š»ÊÛG‹h§ ì n£°úü%øs3Eâ\ë !/ö1CrD¥†Ö& ÖGVz£�£²þBŠ­	‚�×.ÀÉ=Lk´¹ùa
I6C|øO¢ —…y~	žÏF´ë+êÄdâb˜ ZU ¡ö°k	—	¼	ä	û
œ_¬´¶ôÀ9‰Ô " ÊFhç6!�	Ç
NXÐG*u¦o|Êêüí «Ì¨ âg~‘Y	œ	¹	æ	
ó�Q¨tØ$Ã%¦õè) S4O{¶Àí³í•Ih°	û	“
GýN‹¹Zå#íx�9ªÉÙq~)/- 6 l W¦$ÔòQc¶Ç	L
j
£
®¼")/´9¦Çamœöt¾sÃÛ-w.ì€PHüë$ ¡½€=]”ö9ý’	0
¥ÂÚ×�ˆ²H…^�–"—´æ5)Ó1 1 P W ° È ÅHÏpã8Amp›ûâ ,0Ä	ö	^
÷
c‹–oÇ'[„›R],
.‘¢4âé‹åþ ù <¹ä*ËÁÅ3osÌÆ 8ïÇ	5	b2Gqâî½í  õ["j>	I�'N¡LTÜ* €fF(9  ‡ :J�p	 	å
]‡—´¥ÁÇwgH  Z — Ì=‘w¯Ð#ÆÞ	8ö¡ á>øT�ÛUËàyM¯h ³ @,KS‹éŒÉ
îT¨:gw
Ì( ž5Ý!V°ñd#a	Î
è
*0=Rr‡Ûñ,¸Ê sì¼ÕkrÍë$•
r& Ë È +.JM¿Ò 
µ
5zˆðÈò£49â*}�ÑekÄúÀo»³n �-Ét{Œ=
PU½A’!Ê;æo{„Š^ï/ & •fåþ;Sw…ÕT	«	Á
q€ÅLÌOÃGªòs¤¨GÙàð_†–,¤ì9 Ãf™' $ 4 02¾bŠÎë~nô*ù	)
J
\
3~º›¿`þ”šr7mc’çfÁl3  S ¨ò—ÖÙî‰ìFŸ»	H	+
¯
²
Ó
ì
ZÒIç
'nªò6K`×5EXü´$†”ÀT¬õy¸Ã* Ò‡ÄÝ
_ä jï¡L	 	ð	õNÚ7„š¶9“Ö‹ž¦Ã¬?Y¨Ê{m  œ ˜
Ž
|CŠ­^-YÿI]œ-ÓÅ^Ý ™"
¹
§ìX}¸eÿ$X2 < 3O[iô¤½ús	é	S
±	$,8AMWb�;zp�ßùvy§h
&¥¸1&–ñÞƒÐ=Ï: I Û  s4çô)µÂÐ)s¦·&š¯½µ	ì	
9
Ž
Õ
\j•ÔÒµ¥®ÜíöQ¦¶*íøqò…®ÂÆû&Ý# _”è¢Îáve§BQ”	[	
o
î
ê™ªMXÜB?	T‚>ø %m‰¢a¯ùªfÖ¿$<[gêjŸF`F{÷BŸ" ÉªE§ „á �–	»	ã	
ú
MFÎEêé§s×³¿n{#Ÿˆìç. V RÎµ# ¼â”ñú<\“á/8HüÃ	/
¢
(üÖÆ±½GZšQ\•Ø!-~–¡³Oäê  ô9î		4	)M1FÄá¼Å'! +ÇU¯®¾Ý	ÿ	´
yïÇñõ)8<qÚ÷S|»Ã9ùjÌºq& –½,aÈÕØýs}ˆ‹óE„I
±
À
p}¹ÄKT¼æ‘“™å³ln‰ôÂ&  Nh�Üù^ÿiîK	Ÿ	è	R
¸
¦°ë#W+@Ù™,·þ\#,XWlÜ2 $^lˆÈ®øDuŸƒæó(¦Ïà¶�“™â	

”EÍ˜¤­ìõ;PZfžEWÖÛ„ž�žë÷(  U óíT®¼+­»á“ð;[7ƒ.
¡
(o'åûÕ7pÅÙ0E¼,}ˆ Â;  fgñò­÷‚¬¹ºÛþµ€�‚�Ž˜J	ž	

-
Q
 
'n“DäéêÌV—£¬ëô/DeÚ)*+{| !"Vƒœ�Û  1Ê  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                       (                                                                                                                                                                                                                                                                                                                7                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
                                                                                                           %                            #                                                                                           6                                            	                                                                               	                                                     "                                    >   .      
   	      	   	         
                           	         !                     	               
               2   '      -   "      "   ,   *   !   °   W      "      &         e                    (                                                                                                                                              7                                                                                                                                                                                                                                                                                               
                                     %          #                                 6                	                           	                   "            > .  
 	  	 	   
         	   !       	     
     2 '  - "  " , * ! ° W  "  &   e   }�  ~õ    q  „£  Šw  ‘Éß«C44´$Òí¯½4¬­®¹æýúˆ¶·7š¡é	 
¡
¢
(õÕb}�¶?íÿ¥¼Rµý9åJ 3°]x	÷xªá[½ê/½MÇÍÉéŒ/ËåJ¢¿¾ MÇçkƒ¶Í•:Cým¢%)Lf	Â	ï	õ	›Š¢ßá&D¿:‰�‡Ûò}ƒøKV×WšEÉ
Ž
}øÓÊ
BRœšÖ;B`RBRBšBóbâgGOîUµ¥íø	0�æØTy¹o	ô
& yøáê „©sT/óïÀ
(„Æ	!„² 2bóÅ™Ûµ¶�4¢µ«óž»ðõÄd½þ(“
Á�Ár4ï¶Ár§ú´í`gð ú3ù™[.”ó
5Ê”ï|�•¸Ý#$ù§w›/˜ž8­ºÁ#¬p	ç8æmˆ<Û~ Ò	/	m$QÃìÈžr§ú´•S¢oí‹ã �Ýôø …~	Ü -š­{	Á�ò ­{	ò^tÿŒUÙ¶£ÿ \z÷2Ä?~ ¶ð­h	{	£\¹òçæ -š¹¶&
N
$£˜¼kÿdæŠï•÷&Vx)H†Ä'Èf®¢µ÷YP„j0¥×Çæ¥Hò	•_Ñ Ê” Q‰¸	0µ¶·ïa�|I£lx�¨ð•¸Ýû"#�ª}Ë¶É»Ó
ZÒ´¬MLG_ÃÆqšKž´ÄaªÄ,4ÈÛó
()^“”þÿ)‹J	ž	

"
û¤ìgŠÄÙ9FØ}.† ôµ«>z`
x�Cï	ôMÕŠ¥§#±Ö‰¯
Iºp	8æÏ¶­õ²Š¸Žºp	8†.Æ[‡A
aªgFÍ  -š¹¶ð­h	{	&
N
$£˜¼k\¹Áÿ�òÙÆ{ªšÝ`aªgÄF3clóÅw Mz~Írø.2«%.2Lgf	´	Â	ë	ï	8
ei´Ñ‚†"M±Äù*ä¿#'PTŠ¥)–ì>Åaª"
gF†Ä'ÝK  ªòA7¿[f¼ÈÈÙÏ ¿KV.À´ºàF6*ü^ÿÙ…+	ªÏâ–ª—ó£7LVa%·ð-š>¶$QÃÉìÈ»Ó
ZÒ´¬¸¯÷uCmÄ	éÆâç gðŽ^	 ç ÀßØ­{	”	±èù`güòð  Í Œ Ô
[ÆÓ{¥ú§ãì?w£ýcÆL®`ª­š  ×ã ›Sa âï	MŠ¥Ñlm	±¶þ+1&Ð‰]ÒÉtU0ÇÑ¶þ+gð‹tLUGM_Ãy¾ßš «G\‘õ"…½¯À@� ) Ò"CvÙó
55|÷R±õð  ªò
A7¿[¼È ¡8�°gÉ™ÚRµ4ô)”Â)H
Ž
ü¥ÜíØøq~¦ˆ—q•A
þšÇ o @Llošksõ	#b nÓý&ƒê-~�3twBŠøØ LQ¶·ß÷b&�5²	
£¤¼š�Ðá¿ÒÄÜ
^_äÿ iîK	Ÿ	ÙÚ™9žXleÂC	mª1"ÿòPÂ¥Qbšá¿ Lks# ÓýêtwBøÇ o@lošõ	bn&ƒ-~�3ŠÖ¿<j`{÷­"Îzñ‹0Ã!
|; Ç ¶¹¼o @Lloyš"ks«o	r	õ	#bÜê �:nyÓØý&}€ƒoÏøxê-~�“	¤3twBŠÝøW<RÒµÄ4Üô
)^_”Âäÿ )iîHK	Ÿ	
Ž
ü¥ÜíÙÚ™9žØøq~Xl�¢A‰-È¸ø	5N8 h
 _�vuM NìF
Y"p}.I  ¦¯½Qò…û&Ýçç˜
��Íæ¬�£²BŠ=Cø& S…Á
ð†,l ¦ÔcÇ	L
")9¦œ-Hš1ÙÚaý3 ¬ž
¡é)C½‘	kÁÎ„ðd·þÔ
& l ³ ï¦SÔc…5	Ç	L
Á
")9¦œ-ð†,H§»°ˆ†áF6�	*uo|üþ§	S¢C‚pNhùè	R
°#+@2�Uf	í1»F¬ “dªBM.Q±Ü�ÎøF	Š
á
@æü{5o”8yÄPRì.=RfBY`ïò5 žO¥.¤TbËí>
K
­»8¥{›ðõsË,‘M›üÄÏGÇ¾ÿ	´
yïÇñ8|Ãùº¯óØ¤ Í17ŽëD	Ž	VùA÷B�õX’+ç© ÷<&y‰SVxóÅÏdÿ*-ILÑ43)Ðd¿² mªMæP“dQ�F	ü5yRD	Ž	VAX+¬ B.±ÜÎøŠ
á
@{o”8Ä; ¶¹¼y"«o	r	Üê�:yØ}€oÏøx“	¤ÝW<F6§»°�	*uo|ˆ†áü§ :CwÚÂ‚6Û#D}Ap V˜v Î ä 4¾e	RÑéýu×$ºCEM—„Ð< 3O[iô¤½ús	é	S
±	$,8AMWb�;zp�ßùvy§h
&¥¸1&–ñÞƒÐ=ÏkŒ	¶¹y�2�"Un«f	o	S“«ÜêíØ}€˜Ï1»FP“š¯Ÿ/°W * Ô Óì#Dw•Úô
Ç6… .y�›uãé·ÒÅê(fuR	_	;
 ·^_ŸÕßÿÉìqw�ì,¢„Þw¶u Å ÃË	ó	Òßèþ Ž–Öû#%	¹D`��Ò6äN×4…Ñù <¹ä*ËÁÅ3osÌÆ   ¡8«¾y¶óøB�áê8°À\go½É2‡™ÇÉÚþÙ L»Â·Óß÷{'‘ñ$5O­q	³	ý	 
·è¤½KˆŽÂ9çn‰=ëöº�ÑÜÒ‡ÄÝ
_ä jï¡L	 	ð	õNÚ7„š¶9“Ö‹ž¦Ã¬?Y¨Ê{m¦ &b«ä2=Î	ÇÙg|‡Åhn(GaÅY„Þ«– î›G … • Ù "LU.6Qy}�›»ÅÌu”ºÂãï!2€ª·ÆÌÓßé÷\{™¤·Ò'Ol‘Åêñ$(5Ofu­´R	_	q	³	Á	Û	î	ý	 
'
;
O
‘
%1hl£·è %-¤ºÔ™¡·½P^l½K_¨ðkˆŽŸ¶ÂÈÕß9JRm†Úãçÿ%q‚•Ô 
n‰�²ÉÙ�¨ìqw�ÁÖì,=�¢ëö"„Þ*yºÅðu�ªÄÈÑmw¶Ü ? ¦ à &(*;‚Šâä&.b#%k«ä]F™2=	Î	ÇÙgs|‡ž5¼Å%h€åUn‡(Ga©�ÅðYa„Š»ÊÞgÛ˜«óõ÷Gj– îôT‹h›§s¨ûLµÝ†	D
Ÿ;Gµàì
Å™9®î  ¤ 54B®×ã1|	_
"d,¾Ç‚Î)Èw…é-/=Œæ§ÿó ¡ [|ThÓØ	)	0	)ny}Ïsž¯úÓ–½,aÈÕØýs}ˆ‹óE„I
±
À
p}¹ÄKT¼æ‘“™å³ln‰ôÂe ³ÕW†Ø
/+X¡$o¨†Œ±´ÀHÐ5MP”!rD ‚  ]†Œ~V�`,	Ê
«äóUfq{ø3œÐÕã*—f … s¨û*Lµ.y�›ÝuÖã`†Ÿé·ÒùÅê(fu¦	R	_		;
D
xŸÃî ;?·G^�µàì_ÞŸÕß0°ÿ
R™ÅÉ[‡ìkqw�ì ,¢Q„²Þêý•ø™Ä&9w¶®éîW0uZ„ÀVƒ¾“£»ß�@mhAâñ  %d      p  v         v¿þ`�îÒu¸îód¥=&ã¿ŽˆŠ,á$ŒÄÕjS�uC¡ñÖ�…ã¤
C*Œã¬Æ'Ñ™Ì¡Úhy)¥’[Zpi+dý™�+Ì§eéÂVÏƒ‡Ï×üý¡ËYaÉŠý’\õ�¯hrÖšœ%xýè4�µ"m˜õ'?ù¡ËXp•ƒóàÚcô�‡é€z¾z'nri-³š}‚Â¨4�µ€È0¨{p¯RïÚµ€JŠ ßUµÀz½V,—^óý¡ÍX$2'.fSDîàåäEýã§ƒ¦ÅigÞdSƒ“*W¥:	ñ;÷’ôˆ ZãFoMÒ<ìAçT}‡i•aÛuaÔ’?*Wó†Óìx�®J==¸¢£þÿÈúúàP�{÷‹êùeXAZ6Í¢á$"Úæ¸  AÓP€QÖMŽ cæ¸CEôàä ›ýÌþ$Ã6”Ì0")ÌÓ!ó�èôÏäÏÎú³«¯ëêì÷+<:¿ËS¹[ ;ú�+Æ¤Ž§ûõUèi+rHlþ*¬þ¡Ê½ÊêY {¢½^×{_æì.kª™@j�°ù ¥U„á©uV¥ÌZZâˆ‹J@ˆ/ô;ý44RcTØÛµ¤´×Ðˆ/ô;ý44RcTØÛµ¤´×Ù/Ïù{ÏÛóþ^óô¯?k¼ÿ`áåªªjcD<CÏ¸û„æ½’Cª Cä:£UNüè™½ªÁ¸mDtA²¬Øh]F�Í
ï:CšÃ˜x×G[;†<ò+Ã‹LÐü+ª‹Qñø¼#øX^4CLÃ› à÷¯£4â;¢ÞÀP9 1Hðï‹nß£¾<EI½¶Ö0Ã�œèo~?k}LWlÛr{<.‹A†àqDÛ@;3ÓÅâ³ÐíC3cñÃnË!ýƒøèñfØ UƒÎ«�­±â Áó›AÙ2ƒŸÈfŽNƒX:û#©Âló¿Í3lúæÏ®‡ºá0à
Åañõ1Ï×ãÛq±¯|óë˜T(°[*¼<8o½3 nØàJë?×¢¦�:e‚�YSY6ÝZ·VTÚª·�®J ¨½^ÛX›¦Ø¸™òÇîNDè2[`¶N*øˆVŠo;u¯w]œO6T‰Sàùa!9{v–Œ£;xüêô°ø²=8ÚX[\ÌÂ£&€ÎëÎ¾ÎÞÎ3°²°ãL&Ó·µC	g
ot[@sAQv!5PôÕCÐ_%T<Ê82ªöC¼ÿøq6ÝU±ÎÔ´BWñÐy•ô2¯þ;û#;¾+Çøó§ÁŸ‹Ï«¿¬2êí“·8�›´¬"BÊÎõ8"7ÿÊÓñóŒúo	y²èK×ð”w›=àÓOx%Ði4LBbCçD®… ƒåçw‘EÒj	¸Îã…=)úÁU‚Nèo]_|à“
ªŠ�M4iÌÑUPnÔQ¾¡º®p‡;H{r”¨-„iµT­ùê•¥VªVÖåI™„•è.)õŽ–Òß›´Æâæ¬­½’�‡¿Ë"F^qœŸnôŽ5†|Äs·Ã½›Me}=<4Rã^¦óïoKšZ(ðäII+=)d¨ÍrŠ=£�²·;,¨&¶´ï
ýqµJvÿbˆÕTÂ“¾°¾ñ²‹E%(<Ò)·¶
`ÓxÙkºx¶=¼”cªâIí}Kk„Y"c|J;£ðËYÀeŸ3Ý“EêU#¶Ú\®°UîÔ§Î(Fô¬b_ÞÈß×†ëMº§«}2®Ut5XóUPP1ÜŠ{gºú«Y¦…6¦Ð)¢í„Á�š…‰©Y]Y ¯3v¯ñT�~  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  á<?xml version="1.0"?><Features recycledIDs="16" nextValidID="17"><Feature recentID="15" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3364-3380" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="T7 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="863-881" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="3433-3454" color="#31849b" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="3388-3394" color="#ffffff" type="standard"/><Segment range="3395-3412" color="#ffffff" type="standard"/><Segment name="-35" range="3413-3418" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="3xFLAG" directionality="1" translationMW="2730.72" type="CDS" allowSegmentOverlaps="0" cleavageArrows="1056" consecutiveTranslationNumbering="1" maxRunOn="1059" maxFusedRunOn="1059" detectionMode="exactProteinMatch"><Segment range="991-1056" color="#cc99b2" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;three tandem FLAGÂ® epitope tags, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="codon_start"><V int="1"/></Q></Feature><Feature recentID="10" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5359-5463" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3170-3291" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1986-2121" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="615-818" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="bGH poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1094-1318" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1806-2135" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="235-614" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1364-1792" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="RIGHT"/></Q></Feature><Feature recentID="2" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3742-4327" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="direction"><V text="LEFT"/></Q></Feature><Feature recentID="1" name="Neo" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="2202-2996" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="0" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="5289" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="4498-5289" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="5290-5358" color="#ccffcc" type="standard" translated="1"/><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="codon_start"><V int="1"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ><Notes>
<UUID>4ff05e09-b66c-469c-8065-75f8cff75ce8</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<Created UTC="16:0:0">2017.6.5</Created>
<LastModified UTC="1:52:46">2023.7.4</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Ìý7zXZ  æÖ´F !   t/å£à	Š] Ë‡ØÎf‘ƒÊý{3Ôé·Ú(1v%f M*	mj÷)p80çÌ*iÚ	´NY]Qó“�úF7î&ƒÕ!Ò÷ÀnÉ;_x‰Ö*®é�æÑgíH¥¯¼…²@¤À°CÓ?ìßþ*^DIGŒ¡%Ñup›Ÿ“«¹!™XøgŒŠ
”()NùP›ó¿x9/q�Ù´ÒB´Æ‹¤Í³Š„3ˆÙ¶;ÀÈ	ö^,ñŠ—“4ˆÑ@øªñ+ú‹(HÑ§›tôÎ¨ª��âŒýX›t'05LüôV ,°àÊ4ŒS¦ÆáÿPà‡¹Òùž­`–N_Zgð÷}¸Á|ú»lz6��ÿå³l’Y~•ƒÄÒÙ™›uk•³ÞâGwöq,›Gñ¡ŠÜ.C@%òOÈZÇM2Ô¤;jø`Øîä{�8wùX˜‰iËûíÁ@»bÃÞHwÀ§Ñ /Ûz�n41šÒ
E´­y<Œ-2¼mLâ? G½÷®íè†êÞj¹^\ÜRÒ­nãŽI/‡•Aéï
|¯F ïÉªó>éí+ØÑÕˆhçëÏ)Œf®§—A)æ¸i:Œ;A6E"u�`È‰ðuåÐ¿ïÛüú%�pT5%SÑÑ«÷÷�ItXÉÎÍ¾“O,-±0ÀŸ°š’’Eö¶éå]gÅv£Ukm¥˜@Ä÷‹¯TÐë>R¾ùôüdFY1ƒï� ã¤N„¦:U€–úÊµí%�O²~¿�ø²ZÒ¶Ãð8o©=<jc±2Æ*ÖÛlÓ}½6@M&{!ëí‘M­yòE:‘aËŸ5àz‚¬:�M�$oÈ³•+�L+Z¥�\ "¤0õê‡WÃ3ˆ»hÁWòZo³ëò\I¿gýWœwÞç!á+ G÷g‚¶‘`û2lŸ7e±?Õ0?èiF'ÊQ•§Ï¼öGbÇPw#6—xËu9ÕëÇ½c^
¬Rÿ6Ê»©_¾_Ó¤€ˆ·ë	íS4ß‡Â;˜uÖ˜wf9ãèø}´ŽsŠSÕNDƒ�+d8Íipt	#;B*ûuPädÏ£Â¡rPÿñObRuéXxðß^;ÖæŠ³uºhÞoO9nJ§`p-Ò1Õïéœq•À—P(Ç‰m¶‡I½w`!@8Ì‹÷™	•m™ž³¬(ÑV‚4æ­}43æðŠÆà–¤�Ï	DÜÇ«”¥éëfd¬„â¸(×É,¾T-?““¸Ux›s,[ÑKæèØ­sAä ]t±ZK¼PšyaóÈ­E”ž¡ï¾ç‘•T²Yµ’QP×|N­¬Òbd×‚-PxÔ«Ó‘Ú~o ëçÿ”iPß!qŸê5¶åÔH`Ö×…¢˜UH8åLûž�.ˆ†þòùµ3lj�éØÐÞVñÙ¸Ì!Vv‹o€º½1Ù,

¦}^Pû/�Û¡©
W¾�Ó·²ÖºJKµ?ŒÚ‹„Ë;Vz"Ty5…N-`W"Ëlâ¦ã_,"‹þ¤�iÑÄ–*ŽkÉ?ìUeIƒnLã’<)tÕi85’\rÆ
Ï‡ãQWD*~•q�‚©ÉÂò·Ú¡o»³ÿP“¯Þ[ùK)V„ÕÂ%Sºí5´Å âûÛð?‡îóP¡=½Üóàhö/[ñrË6€‘²ºÁEÄ\¯ZYá¬Uà³½“ôôž™»äñ8ñíîÄ·§ ^Eµžâ7¥P¸žâo¯VX¤•gæa´nô0÷Õ‡›Ök�Âû'¼J�o(±¥Ti›¢6ÇÚ³xú€‚¥
µ žè¬ÑKp*JãÜZE}L`ˆÏê‡ÔÕœ(ö]=á›Dõð•ÜUW“ÙZ‹xFC³Á ^µ]K˜×›Òû}¾6,D¼ãÙ×ñÔø¦©x8{´ïx•±Ó]ó¥ËÒOŸaê¤ÞÏóUë³S™zµ[Ð‘>Z6`š,gÕÇöÆ�C®ÖÉã<ô¿Ö`À)›pl}tKÙpÈú½C.ç#×èäŸÁ™(î—Ï1nµèƒ¬Ó 
T|àß¡Õ7%Û7»Á®{rc.H5øÛ·Tµw°ç´žTgCû
Šp5"ó£àD22W%sgC©Õ5Î¸v¥Ñ†äÐaíñã§/Gñ“e«—SþßbßGîX#:4ÇàèUý1´¾ÉØ%"—¬+�F'ÍaõASðê0Œ•Š�ê     ·Kúì-š ¦Š0  PQR±Ägû    YZ   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  &
<?xml version="1.0"?><Features nextValidID="18"><Feature recentID="0" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="7462" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="6671-7462" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="7463-7531" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="1" name="Neo" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="4375-5169" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MIEQDGLHAGSPAAWVERLFGYDWAQQTIGCSDAAVFRLSAQGRPVLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTEAGRDWLLLGEVPGQDLLSSHLAPAEKVSIMADAMRRLHTLDPATCPFDHQAKHRIERARTRMEAGLVDQDDLDEEHQGLAPAELFARLKARMPDGEDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQDIALATRDIAEELGGEWADRFLVLYGIAAPDSQRIAFYRLLDEFF*"/></Q></Feature><Feature recentID="2" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5915-6500" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="3" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3537-3965" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="4" name="CMV enhancer" type="enhancer" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="235-614" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus immediate early enhancer&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3979-4308" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="bGH poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="3267-3491" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="615-818" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4159-4294" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="5343-5464" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="7532-7636" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="3xFLAG" directionality="1" translationMW="2730.72" type="CDS" allowSegmentOverlaps="0" cleavageArrows="3229" consecutiveTranslationNumbering="1" maxRunOn="3232" maxFusedRunOn="3232" detectionMode="exactProteinMatch"><Segment range="3164-3229" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;three tandem FLAGÂ® epitope tags, followed by an enterokinase cleavage site&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="DYKDHDGDYKDHDIDYKDDDDK"/></Q></Feature><Feature recentID="12" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="5561-5567" color="#ffffff" type="standard"/><Segment range="5568-5585" color="#ffffff" type="standard"/><Segment name="-35" range="5586-5591" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="5606-5627" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="T7 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="863-881" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" visible="0"><Segment range="5537-5553" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="Kozak sequence" type="regulatory" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="935-944" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;vertebrate consensus sequence for strong initiation of translation (&lt;a href=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot; title=&quot;https://www.ncbi.nlm.nih.gov/pubmed/3313277&quot;&gt;Kozak, 1987&lt;/a&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="regulatory_class"><V predef="other"/></Q></Feature><Feature recentID="17" name="GTSE1" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="3232" maxFusedRunOn="3232"><Segment range="941-3157" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MEGGGGRDEPSACRAGDVNMDDPKKEDILLLADEKFDFDLSLSSSSANEDDEVFFGPFGHKERCIAASLELNNPVPEQPPLPTSESPFAWSPLAGEKFVEVYKEAHLLALHIESSSRNQAAQAAKPEDPRSQGVERFIQESKLKINLFEKEKEMKKSPTSLKRETYYLSDSPLLGPPVGEPRLLASSPALPSSGAQARLTRAPGPPHSAHALPRESCTAHAASQAATQRKPGTKLLLPRAASVRGRSIPGAAEKPKKEIPASPSRTKIPAEKESHRDVLPDKPAPGAVNVPAAGSHLGQGKRAIPVPNKLGLKKTLLKAPGSTSNLARKSSSGPVWSGASSACTSPAVGKAKSSEFASIPANSSRPLSNISKSGRMGPAMLRPALPAGPVGASSWQAKRVDVSELAAEQLTAPPSASPTQPQTPEGGGQWLNSSCAWSESSQLNKTRSIRRRDSCLNSKTKVMPTPTNQFKIPKFSIGDSPDSSTPKLSRAQRPQSCTSVGRVTVHSTPVRRSSGPAPQSLLSAWRVSALPTPASRRCSGLPPMTPKTMPRAVGSPLCVPARRRSSEPRKNSAMRTEPTRESNRKTDSRLVDVSPDRGSPPSRVPQALNFSPEESDSTFSKSTATEVAREEAKPGGDAAPSEALLVDIKLEPLAVTPDAASQPLIDLPLIDFCDTPEAHVAVGSESRPLIDLMTNTPDMNKNVAKPSPVVGQLIDLSSPLIQLSPEADKENVDSPLLKF"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  ¨<Notes>
<UUID>39c02662-6cb6-48af-9de9-4c8c77467e68</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pCMV-GTSE1(human)-3Ã—FLAG-Neo</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="16:0:0">2017.6.5</Created>
<LastModified UTC="23:33:17">2025.9.20</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y     K         
?????                                                                                                       ÿ d      DO  d               E              ÿÿÿÿYô? P                                                                                                                                                             o<StrandColors><TopStrand><ColorRange range="938..979" colors="green"/><ColorRange range="1006..1006" colors="magenta"/><ColorRange range="2512..2512" colors="magenta"/></TopStrand><BottomStrand><ColorRange range="938..979" colors="green"/><ColorRange range="1006..1006" colors="magenta"/><ColorRange range="2512..2512" colors="magenta"/></BottomStrand></StrandColors>   3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
